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Manuscript preparation and publication is a cornerstone of medical knowledge. The published manuscript is the “coin of the realm” in academic medicine, the specie by which physicians and scientists alike are judged relative to their peers; it is also considered an indicator of future potential and current achievement. The importance of publications is highlighted by their central role in academic advancement. There are several broad groups of manuscripts. These include original scientific articles, invited reviews and editorials, and case reports. 1) Original Scientific Articles: Basic or translational research studies may answer fundamental questions about basic mechanisms or physiology of disease by testing specific new hypothesis in in vitro and in vivo experiments, resulting in new findings. They follow rigid, well-defined protocols. These studies include those with “clear biological interest and implications for the treatment of human diseases and represent a novel conceptual advance.” The best of this type of research will have broader implications to the scientific community outside cardiology and may be considered for publication in general scientific journals. Clinical studies that have the highest academic merit are those that are prospective, hypothesis driven, randomized if possible, double blind in design, and adequately powered to address the specific question posed. Such studies form the basis of practice guidelines. All randomized clinical trials must now be registered before the trial is begun to ensure that journals will consider their results for publication. Registry series are a subtype of original research article. They typically involve patient populations in which the outcome, both long and short term, of a therapeutic strategy, new drug, or new device is addressed (ie, large international registries). They may be single-center, multicenter, or multinational studies. As with all scientific manuscripts, a specific hypothesis and adequate sample size are required. A subset of this type of manuscript is the retrospective observational study from populations at the author’s own institution. Many institutions have robust databases of a large number of patient groups. Manuscripts from this source may be ideal for trainees because the data are readily accessible. Meta-analyses are a kind of publication that has become increasingly popular, and a whole field of study has developed around the methodology. Meta-analyses require considerable statistical skill, multicenter or multinational data, and the ability to combine widely different data sets. Disadvantages of meta-analyses include incomplete data ascertainment in the data sets, the use of disparate definitions for the same terms in different studies, and major differences in statistical design. Optimally, individual patient data should be analyzed. 2) Review Articles: Such articles serve a very real purpose for younger, mentored physicians early in their careers. They require that the author extensively review and master the literature and then develop some general statements and conclusions with implicit implications for patient care strategies. Review articles provide a coherent reference base to the readership. The process of writing a review article can often be an integral part of medical training and mentorship. Review articles are often written as a result of an invitation from a journal. Preparing a review article can occasionally bring to light a clinical problem that then can be addressed prospectively in a well-designed study. Similarly, for a basic science trainee, writing a review article allows complete analysis of the literature in the trainee’s specific area of scientific interest. 3) Editorials: Like review articles, editorials usually are invited. They generally provide scientific or clinical context to concurrently published articles or issues. Often, the invited author has been involved in the review process. Like the review article, writing an editorial can be a mentored experience. 4) Case Reports: As primary caregivers in academic institutions, young physicians frequently identify unique patient cases worthy of publication. The case report exposes authors early on in their career to the issues of manuscript preparation and publication. They are very well circumscribed and offer the opportunity for creative use of visual graphic material for the case at hand. A disadvantage is that many journals do not publish case reports. Thus, it is very important to have a specific journal in mind before initiating the project. There are metrics for evaluating the importance of a specific type of manuscript to young investigators. Factors to be taken into consideration include the goal of the manuscript and the goals of the author and the mentor. For academic advancement, manuscripts that require development of a specific hypothesis to be evaluated using new original data are more important than review articles or case studies. However, both of the latter also are important and useful to encourage trainees to develop writing skills and to critically master a body of literature.
There are multiple steps and multiple goals in the preparation of a manuscript and its subsequent publication. Gaining some understanding of these issues is crucial before taking on the actual practical task of turning ideas and concepts into a finished product. The primary goal of publication is communication. However, the means and form by which the communication takes place may vary widely. The goals of preparation and publication depend in part on the author and the landscape in which crafting the manuscript occurs. Sometimes manuscripts are the outcome of an experiment or research project; at other times, they fulfill a requirement of a training program. Some manuscripts result from a comprehensive review of a subject matter or field (as in a review article). Regardless of the landscape, it is critical to begin by defining what is to be communicated and to whom it will be targeted. Preparation of a manuscript for publication begins with a clear delineation of what is to be communicated. Once this task is completed, the primary aim is to write a manuscript in a format that attracts editors and reviewers and effectively educates readers. It might be said that an unpublished manuscript and an uncited published article are the 2 ultimate failures of communication and education. Another failure is related and equally important. It results from a series of events that include manuscript preparation and submission followed by several rejections, which a young investigator perceives as failure, becoming discouraged and hesitant to attempt other academic ventures. Achieving the goals and tasks of planning, preparing, submitting, and publishing academic manuscripts is the focus of this article, which is aimed at young investigators. Do note that the above general tips are provided only for your understanding. Whatever be the manuscripts required, you can depend on us. Read below for more details.
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